| First Author | Matveeva TM | Year | 2019 |
| Journal | Brain Behav | Volume | 9 |
| Issue | 10 | Pages | e01383 |
| PubMed ID | 31515952 | Mgi Jnum | J:293645 |
| Mgi Id | MGI:6453131 | Doi | 10.1002/brb3.1383 |
| Citation | Matveeva TM, et al. (2019) Sociality deficits in serine racemase knockout mice. Brain Behav 9(10):e01383 |
| abstractText | BACKGROUND: Studies of schizophrenia have pointed to the role of glutamate in its pathophysiology. Mice lacking D-serine show impairments in neurotransmission through NMDA receptors and display behaviors consistent with features of schizophrenia. Yet, socio-communicative deficits, a characteristic of schizophrenia, have not been reported in serine racemase knockout mice. METHODS: We use behavioral testing (the three-chambered social approach task, the dyadic interaction task, and the novel object recognition task) to examine socio-communicative behaviors in these mice. RESULTS: Serine racemase mice show abnormal social investigation and approach behavior, and differ from wild-type controls in the duration and number of vocalizations they emit in the presence of a conspecific. Serine racemase knockout mice were not impaired in a cognitive test (novel object recognition), although they displayed abnormal behavior in the acquisition phase of the task. CONCLUSIONS: Serine racemase knockout mice demonstrate abnormalities in socio-communicative behaviors consistent with an impairment in sociality, a negative symptom of schizophrenia. |
