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Publication : Neuronal actions of glucocorticoids: focus on depression.

First Author  Yu S Year  2008
Journal  J Steroid Biochem Mol Biol Volume  108
Issue  3-5 Pages  300-9
PubMed ID  17933520 Mgi Jnum  J:132414
Mgi Id  MGI:3775900 Doi  10.1016/j.jsbmb.2007.09.014
Citation  Yu S, et al. (2008) Neuronal actions of glucocorticoids: focus on depression. J Steroid Biochem Mol Biol 108(3-5):300-9
abstractText  Stress, acting through glucocorticoids (GC), has profound effects on brain physiology and pathology and is causally implicated in depressive illness. Here, we consider the information derived from genetic models generated to probe the role of the hypothalamo-pituitary-adrenal axis in depression. This essay also briefly reviews the status of knowledge regarding GC actions on neuronal birth, survival and death from the perspective of the importance of these phenomena in depression.
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