| First Author | Tarussio D | Year | 2014 |
| Journal | J Clin Invest | Volume | 124 |
| Issue | 1 | Pages | 413-24 |
| PubMed ID | 24334455 | Mgi Jnum | J:207618 |
| Mgi Id | MGI:5559252 | Doi | 10.1172/JCI69154 |
| Citation | Tarussio D, et al. (2014) Nervous glucose sensing regulates postnatal beta cell proliferation and glucose homeostasis. J Clin Invest 124(1):413-24 |
| abstractText | How glucose sensing by the nervous system impacts the regulation of beta cell mass and function during postnatal development and throughout adulthood is incompletely understood. Here, we studied mice with inactivation of glucose transporter 2 (Glut2) in the nervous system (NG2KO mice). These mice displayed normal energy homeostasis but developed late-onset glucose intolerance due to reduced insulin secretion, which was precipitated by high-fat diet feeding. The beta cell mass of adult NG2KO mice was reduced compared with that of WT mice due to lower beta cell proliferation rates in NG2KO mice during the early postnatal period. The difference in proliferation between NG2KO and control islets was abolished by ganglionic blockade or by weaning the mice on a carbohydrate-free diet. In adult NG2KO mice, first-phase insulin secretion was lost, and these glucose-intolerant mice developed impaired glucagon secretion when fed a high-fat diet. Electrophysiological recordings showed reduced parasympathetic nerve activity in the basal state and no stimulation by glucose. Furthermore, sympathetic activity was also insensitive to glucose. Collectively, our data show that GLUT2-dependent control of parasympathetic activity defines a nervous system/endocrine pancreas axis that is critical for beta cell mass establishment in the postnatal period and for long-term maintenance of beta cell function. |
