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Gene Segment : Iglc1 immunoglobulin lambda constant 1

Primary Identifier  MGI:99546 Organism  mouse, laboratory
Chromosome  16 Mgi Type  gene segment
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in external side of plasma membrane. Part of B cell receptor complex. Orthologous to several human genes including IGLC6 (immunoglobulin lambda constant 6).
PHENOTYPE: Knock-in mice homozygous for a PGK-neo insertion and a serine codon mutation show altered kappa and lambda B cell number. Knock-in mice heterozygous for the same PGK-neo insertion and a valine mutation show abnormal immunoglobulin light chain V-J joiningwhile homozygotes show reduced B cell number. [provided by MGI curators]
  • synonyms:
  • immunoglobulin lambda chain, constant region 1,
  • Clambda1,
  • MGD-MRK-16324,
  • Iglc1,
  • immunoglobulin lambda constant 1,
  • Igl-C1

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

2 Involved In Mutations

Trail: GeneSegment

0 Strain

0 Transcripts

0 Transgenic Expressors

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

26 Pathways

Trail: GeneSegment

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For