| Primary Identifier | IPR044441 | Type | Domain |
| Short Name | DICER_DSRM |
| description | Dicer endoribonuclease plays a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs [, , ]. Dicer contains a double-stranded RNA binding motif (DSRM) at the C terminus. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure [].This entry represents the DRSM domain found in Dicer and related proteins. Dicer has been linked to human cancers [, , , ]. |
