| Primary Identifier | MGI:95727 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 14632 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in positive regulation of DNA-templated transcription and regulation of osteoblast differentiation. Acts upstream of or within several processes, including central nervous system development; liver regeneration; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human GLI1 (GLI family zinc finger 1). PHENOTYPE: Homozygotes for a targeted null mutation are apparently normal, but homozygotes that are also heterozygous for a Gli2 knockout die soon after birth with multiple defects, while Gli2 knockout heterozygotes are normally viable. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
