| First Author | Schuman J | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 19 | Pages | 4566-74 |
| PubMed ID | 19196865 | Mgi Jnum | J:148728 |
| Mgi Id | MGI:3846282 | Doi | 10.1182/blood-2008-08-176057 |
| Citation | Schuman J, et al. (2009) A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood 113(19):4566-74 |
| abstractText | The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor kappaB (NF-kappaB) activation and T-cell development. However, the role of TAK1 in B-cell receptor (BCR)-mediated NF-kappaB activation and B-cell development is not clear. Here we show that B-cell-specific deletion of TAK1 impaired the transition from transitional type 2 to mature follicular (FO) B cells and caused a marked decrease of marginal zone (MZ) B cells. TAK1-deficient B cells exhibited an increase of BCR-induced apoptosis and impaired proliferation in response to BCR ligation. Importantly, TAK1-deficient B cells failed to activate NF-kappaB after BCR stimulation. Thus, TAK1 is critical for B-cell maturation and BCR-induced NF-kappaB activation. |
