| First Author | Bleackley RC | Year | 1988 |
| Journal | FEBS Lett | Volume | 234 |
| Issue | 1 | Pages | 153-9 |
| PubMed ID | 3292281 | Mgi Jnum | J:24186 |
| Mgi Id | MGI:71940 | Doi | 10.1016/0014-5793(88)81323-1 |
| Citation | Bleackley RC, et al. (1988) Isolation of two cDNA sequences which encode cytotoxic cell proteases. FEBS Lett 234(1):153-9 |
| abstractText | Two cDNAs which cross-hybridized with cytotoxic cell protease genes were identified in a library generated from a cytotoxic T cell line. Sequence analysis revealed that the two new members of the family contained the three catalytic triad residues which characterize the active sites of serine proteases. A comparison of the protein sequences revealed not only a high degree of homology but also the conservation of some unusual structural features. These include the lack of a disulphide bond which spans the active site serine, the presence of a signal sequence and the inference of a dipeptide activation sequence. |
