| First Author | Watanabe K | Year | 1991 |
| Journal | J Biol Chem | Volume | 266 |
| Issue | 5 | Pages | 2709-11 |
| PubMed ID | 1847130 | Mgi Jnum | J:30995 |
| Mgi Id | MGI:78305 | Doi | 10.1016/s0021-9258(18)49902-4 |
| Citation | Watanabe K, et al. (1991) Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme. J Biol Chem 266(5):2709-11 |
| abstractText | The oxygenation of an aldehyde, 11-oxo-delta 8-tetrahydrocannabinol to a carboxylic acid, delta 8-tetrahydrocannabinol-11-oic acid was catalyzed by cytochrome P-450 MUT-2 purified from hepatic microsomes of male ddN mice. The oxygenation mechanism was confirmed by the incorporation of oxygen-18 from molecular oxygen into the carboxylic acid formed. An aldehyde form but not a hydrated form of 11-oxo-delta 8-tetrahydrocannabinol may be a substrate for the cytochrome P-450. The oxygenation of aldehyde catalyzed by cytochrome P-450 might be a common metabolic reaction in biological systems, and should be considered as an additional role of cytochrome P-450 in biotransformation of endogenous compounds and xenobiotics. |
