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Protein Coding Gene : Tnfaip3 tumor necrosis factor, alpha-induced protein 3

Primary Identifier  MGI:1196377 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  21929
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables kinase binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within establishment of protein localization to vacuole; positive regulation of protein catabolic process; and protein K63-linked deubiquitination. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; heart; and retina. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3).
PHENOTYPE: Homozygous null mice display runting, severe multi-organ inflammation, hypersensitivity to lipopolysaccharide and TNF, and premature death. Older mice homozygous for point mutations that disrupt deubiquitinating activity develop splenomegaly and show an increased number of myeloid cells. [provided by MGI curators]
  • synonyms:
  • tumor necrosis factor induced protein 3,
  • A20,
  • Tnfaip3,
  • zinc finger protein A20,
  • Tnfip3,
  • tumor necrosis factor, alpha-induced protein 3

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

16 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For