| First Author | Shi W | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 6 | Pages | 663-73 |
| PubMed ID | 25894659 | Mgi Jnum | J:232662 |
| Mgi Id | MGI:5779770 | Doi | 10.1038/ni.3154 |
| Citation | Shi W, et al. (2015) Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells. Nat Immunol 16(6):663-73 |
| abstractText | When B cells encounter an antigen, they alter their physiological state and anatomical localization and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs). We have defined the transcriptomes of many mature B cell populations and stages of plasma cell differentiation in mice. We provide a molecular signature of ASCs that highlights the stark transcriptional divide between B cells and plasma cells and enables the demarcation of ASCs on the basis of location and maturity. Changes in gene expression correlated with cell-division history and the acquisition of permissive histone modifications, and they included many regulators that had not been previously implicated in B cell differentiation. These findings both highlight and expand the core program that guides B cell terminal differentiation and the production of antibodies. |
