Primary Identifier | MGI:1930136 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 56523 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in spermatogenesis. Acts upstream of or within gene expression and spermatid development. Located in cytoplasm and sperm connecting piece. Is active in sperm flagellum; sperm head; and sperm head-tail coupling apparatus. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Used to study male infertility and spermatogenic failure 31. Human ortholog(s) of this gene implicated in spermatogenic failure 31. Orthologous to human PMFBP1 (polyamine modulated factor 1 binding protein 1). PHENOTYPE: Male mice homozygous for a null allele are infertile due to acephalic spermatozoa. [provided by MGI curators] |