| First Author | Bhadra S | Year | 2009 |
| Journal | J Virol | Volume | 83 |
| Issue | 1 | Pages | 484-8 |
| PubMed ID | 18922863 | Mgi Jnum | J:143276 |
| Mgi Id | MGI:3826312 | Doi | 10.1128/JVI.01374-08 |
| Citation | Bhadra S, et al. (2009) BALB/Mtv-null mice responding to strong mouse mammary tumor virus superantigens restrict mammary tumorigenesis. J Virol 83(1):484-8 |
| abstractText | The absence of endogenous mouse mammary tumor viruses (MMTVs) in the congenic mouse strain, BALB/Mtv-null, restricts the early steps of exogenous C3H MMTV infection, preventing the superantigen (Sag) response and mammary tumorigenesis. Here we demonstrate that BALB/Mtv-null mice also resist tumor induction by FM MMTV, which encodes a stronger Sag compared to C3H MMTV. In contrast to infections with C3H MMTV, Mtv-null mice show FM-MMTV Sag-specific responses comparable to those observed in susceptible BALB/c mice. Neither virus shows significant replication in the spleen or mammary gland. Thus, Mtv-null mice restrict MMTV replication and mammary tumorigenesis even after a robust Sag response. |
