Primary Identifier | MGI:1913993 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 66743 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination. Acts upstream of or within dorsal/ventral neural tube patterning; noradrenergic neuron development; and protein monoubiquitination. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 23. Orthologous to human RNF220 (ring finger protein 220). PHENOTYPE: Homozygous knockout results in the reduction of the number of motor neurons and some types of spinal interneurons and the increase of other types of spinal interneurons in embryos. [provided by MGI curators] |