First Author | Mott KR | Year | 2015 |
Journal | Immunobiology | Volume | 220 |
Issue | 4 | Pages | 518-24 |
PubMed ID | 25468565 | Mgi Jnum | J:329863 |
Mgi Id | MGI:6851821 | Doi | 10.1016/j.imbio.2014.10.019 |
Citation | Mott KR, et al. (2015) Batf3 deficiency is not critical for the generation of CD8alpha(+) dendritic cells. Immunobiology 220(4):518-24 |
abstractText | Recently, we have reported that CD8alpha(+) DCs, rather than CD8(+) T cells, are involved in the establishment and maintenance of HSV-1 latency in the trigeminal ganglia (TG) of ocularly infected mice. In the current study, we investigated whether similar results can be obtained using Batf3(-/-) mice that previously were reported to lack CD8alpha(+) DCs. However, our results demonstrate that Batf3(-/-) mice, without any known infection, express CD8alpha(+) DCs. Consequently, due to the presence of CD8alpha(+) DCs, no differences were detected in the level of HSV-1 latency between Batf3(-/-) mice compared with wild type control mice. |