| Primary Identifier | MGI:1919202 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 71952 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables histone H3K36 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; and iron ion binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of osteoblast differentiation. Located in nucleolus. Is expressed in skeleton and tibia cartilage condensation. Orthologous to human RIOX1 (ribosomal oxygenase 1). PHENOTYPE: Mice homozygous for a knock-out allele activated in mesenchyme exhibit increased body length and weight, increased ossification with increased bone mass, bone mineral density, and volume, increased osteoblasts; and decrease osteoclasts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
