| First Author | Zhang XL | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 30 | Pages | 12510-8 |
| PubMed ID | 23884954 | Mgi Jnum | J:199790 |
| Mgi Id | MGI:5505318 | Doi | 10.1523/JNEUROSCI.2983-12.2013 |
| Citation | Zhang XL, et al. (2013) Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus. J Neurosci 33(30):12510-8 |
| abstractText | Dendritic spines are a major substrate of brain plasticity. Although many studies have focused on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated regulation of spine dynamics and synaptic function in adult brain, much less is know about protein kinase A (PKA)-dependent regulation of spine shape dynamics during postnatal brain development. Synaptopodin is a dendritic spine associated modulator of actin dynamics and a substrate of PKA. Here we show that NMDA and cAMP-induced dendritic spine expansion is impaired in hippocampal slices from 15- and 21-d-old synaptopodin-deficient mice. We further show that synaptopodin is required for full expression of PKA-dependent hippocampal long-term potentiation in 15- and 21-d-old, but not adult, mice. PKA-induced cAMP response element-binding phosphorylation is normal in the hippocampus of synaptopodin-deficient mice, suggesting that synaptopodin functions independently of cAMP response element-binding. Our results identify synaptopodin as a substrate of PKA in hippocampal neurons and point to an essential role for synaptopodin in activity-dependent regulation of dendritic spine dynamics and synaptic plasticity in postnatal brain development. |
