| First Author | Wieland CW | Year | 2007 |
| Journal | Infect Immun | Volume | 75 |
| Issue | 10 | Pages | 5068-72 |
| PubMed ID | 17664259 | Mgi Jnum | J:125285 |
| Mgi Id | MGI:3758127 | Doi | 10.1128/IAI.00287-07 |
| Citation | Wieland CW, et al. (2007) Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae. Infect Immun 75(10):5068-72 |
| abstractText | Nontypeable Haemophilus influenzae (NTHi) is a common gram-negative respiratory pathogen. To determine the role of the proinflammatory cytokine interleukin 18 (IL-18) during NTHi pneumonia, normal wild-type (WT) and IL-18 knockout (KO) mice were intranasally infected with NTHi. IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. These data identify IL-18 as part of an adequate innate immune response during NTHi pneumonia. |
