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Allele : Col1a1<tm1(CAG-Ezh2*)Meln> collagen, type I, alpha 1; targeted mutation 1, Ari Melnick
Primary Identifier  MGI:5519911 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence, No functional change, RMCE-ready Gene  Col1a1
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
description  The allele was made in KH2 cells that carry Gt(ROSA)26Sortm1(rtTA*M2)Jae and Col1a1tm13(neo/hygro*)Jae. This allele was generated with Col1a1tm13(neo/hygro*)Jae.
molecularNote  RMCE on KH2 cells inserted a cassette into the 3'UTR that contains a CAG promoter, a STOP/neomycin resistance cassette and cDNA for Ezh2 modified by nucleotide substitution (TAC to AAC) to contain the amino acid substitution asparagine for tyrosine at position 641 (Y641N).
  • mutations:
  • Insertion
  • synonyms:
  • Ezh2<Y641N>,
  • Ezh2Y641N,
  • Ezh2<Y641N>,
  • Ezh2Y641N
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

6 Publication categories





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