| First Author | Nonaka M | Year | 1992 |
| Journal | Genomics | Volume | 13 |
| Issue | 4 | Pages | 1082-7 |
| PubMed ID | 1339387 | Mgi Jnum | J:1723 |
| Mgi Id | MGI:50249 | Doi | 10.1016/0888-7543(92)90022-k |
| Citation | Nonaka M, et al. (1992) Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11. Genomics 13(4):1082-7 |
| abstractText | beta 2-Glycoprotein I (beta 2 GPI), a plasma protein that binds to anionic phospholipids, is composed of five repeating units called a short consensus repeat (SCR), which is found mostly in the regulatory proteins of the complement system. Recently the human beta 2 GPI gene has been assigned to chromosome 17, not to chromosome 1 where most of the genes of the SCR-containing proteins are clustered. In this report, we have isolated a full-length cDNA clone of mouse beta 2 GPI and determined the chromosomal localization of the gene. The amino acid sequence deduced from the nucleotide sequence of mouse beta 2 GPI revealed 76.1% identity with that of human beta 2 GPI. A genetic mapping by in situ hybridization and linkage analysis using 50 backcross mice has shown that the mouse beta 2 GPI gene (designated B2gp1) is located on the terminal portion of the D region of chromosome 11, closely linked to Gfap, and is 18 cM distal to Acrb, extending a conserved linkage group between mouse chromosome 11 and human chromosome 17. On the basis of these results, the evolutionary relationships among the SCR-containing proteins are discussed. |
