| First Author | Asano K | Year | 1993 |
| Journal | Int J Parasitol | Volume | 23 |
| Issue | 1 | Pages | 51-6 |
| PubMed ID | 8468136 | Mgi Jnum | J:4997 |
| Mgi Id | MGI:53476 | Doi | 10.1016/0020-7519(93)90097-i |
| Citation | Asano K, et al. (1993) Lymphokine production by mesenteric lymph node cells from BALB/C mice during Hymenolepis nana infection. Int J Parasitol 23(1):51-6 |
| abstractText | Mesenteric lymph node cells (MLNC) prepared from BALB/c mice during infection with Hymenolepis nana proliferated extensively when cultured in the presence of soluble egg antigen, as assessed by measuring 3H-thymidine incorporation. Analysis of Hymenolepis-specific proliferative cells in MLNC by using monoclonal antibody specific for mouse T lymphocyte surface antigens revealed that the proliferative response of MLNC was mediated by Thy-1.2+, L3T4+ cells, that is, helper T cells. Supernatant of MLNC cultured with egg antigen contained large amounts of interleukin-2 and interferon-gamma, but only low levels of interleukin-5. The titer of these cytokines did not correlate with the interval between oral infection and collection of MLNC. These results strongly indicate that the Th1 subtype of helper T lymphocytes respond well to stimulation of H. nana egg antigen and suggest that acute inflammatory responses are involved in host-protective immunity to H. nana. |
