| First Author | Coutts AS | Year | 2007 |
| Journal | EMBO Rep | Volume | 8 |
| Issue | 1 | Pages | 84-90 |
| PubMed ID | 17170761 | Mgi Jnum | J:148063 |
| Mgi Id | MGI:3843429 | Doi | 10.1038/sj.embor.7400855 |
| Citation | Coutts AS, et al. (2007) Mdm2 targets the p53 transcription cofactor JMY for degradation. EMBO Rep 8(1):84-90 |
| abstractText | We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53 transcription cofactor JMY. DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells. At a mechanistic level, Mdm2 regulation of JMY requires the Mdm2 RING (really interesting new gene) finger, which promotes the ubiquitin-dependent degradation of JMY. However, regulation of JMY occurs independently of the p53-binding domain in Mdm2 and p53 activity. These results define a new functional relationship between the p53 cofactor JMY and Mdm2, and indicate that transcription cofactors that facilitate p53 activity are important targets for Mdm2 in suppressing the p53 response. |
