| First Author | Masuhara M | Year | 2003 |
| Journal | Biochem Biophys Res Commun | Volume | 308 |
| Issue | 4 | Pages | 927-32 |
| PubMed ID | 12927808 | Mgi Jnum | J:85359 |
| Mgi Id | MGI:2674182 | Doi | 10.1016/s0006-291x(03)01497-9 |
| Citation | Masuhara M, et al. (2003) Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem Biophys Res Commun 308(4):927-32 |
| abstractText | A mouse homologue of Drosophila germ cell less, mouse germ cell less-1 (mgcl-1), encodes a nuclear envelope component essential for nuclear integrity. To analyze the molecular function of mGCL-1, we carried out two hybrid screening and found that mGCL-1 bound to the gene product of tumor susceptibility gene 101 (tsg101). Effects of mGCL-1 on the expression of MDM2-p53 axis were examined, since TSG101 has been shown to elevate the amount of MDM2 by inhibiting the ubiquitination. mGCL-1 significantly reduced the amount of MDM2 probably by changing the sub-cellular localization of the MDM2 and facilitating the ubiquitination of MDM2. In addition, the amount of p53 was increased and transactivation by p53 was enhanced by mGCL-1. Thus, mGCL-1 turned out to be a factor modulating MDM2-p53 axis by enhanced degradation of MDM2. |
