| First Author | Daniel WL | Year | 1982 |
| Journal | J Hered | Volume | 73 |
| Issue | 1 | Pages | 24-8 |
| PubMed ID | 7069188 | Mgi Jnum | J:6740 |
| Mgi Id | MGI:55213 | Doi | 10.1093/oxfordjournals.jhered.a109569 |
| Citation | Daniel WL, et al. (1982) Genetic regulation of murine hepatic arylsulfatase B activity during development. J Hered 73(1):24-8 |
| abstractText | The ratio of hepatic arylsulfatase B activity of C57BL/6J, SWR/J, and A/J mice is approximately 5:2.5:1. The activity variation between SWR/J and A/J mice can be attributed to the effects of Asr-1, a cis-acting regulatory element near or within As-1 (arylsulfatase B structural locus). However, C57BL/6J and SWR/J mice share similar Asr-1 alleles and have comparable arylsulfatase B activities in nonhepatic tissues. The high arylsulfatase B activity occurring in C57BL/6J compared to SWR/J liver is largely determined by a site near Asr-1 and As-1. The C57BL/6J allele promotes a more prominent spike of liver arylsulfatase B activity at 12 days postnatal age and maintains a higher activity in the adult compared to SWR/J mice. This liver-specific genetic element exerts a trans effect and acts by affecting the accumulation of arylsulfatase B molecules in liver tissue. |
