| First Author | Asadi Shahmirzadi A | Year | 2020 |
| Journal | Cell Metab | Volume | 32 |
| Issue | 3 | Pages | 447-456.e6 |
| PubMed ID | 32877690 | Mgi Jnum | J:296625 |
| Mgi Id | MGI:6469058 | Doi | 10.1016/j.cmet.2020.08.004 |
| Citation | Asadi Shahmirzadi A, et al. (2020) Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab 32(3):447-456.e6 |
| abstractText | Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL/6 mice. To probe the relationship between healthspan and lifespan extension in mammals, we performed a series of longitudinal, clinically relevant measurements. We find that CaAKG promotes a longer, healthier life associated with a decrease in levels of systemic inflammatory cytokines. We propose that induction of IL-10 by dietary AKG suppresses chronic inflammation, leading to health benefits. By simultaneously reducing frailty and enhancing longevity, AKG, at least in the murine model, results in a compression of morbidity. |
