| First Author | van Gisbergen KP | Year | 2011 |
| Journal | Immunity | Volume | 35 |
| Issue | 1 | Pages | 97-108 |
| PubMed ID | 21763160 | Mgi Jnum | J:174514 |
| Mgi Id | MGI:5139922 | Doi | 10.1016/j.immuni.2011.04.020 |
| Citation | van Gisbergen KP, et al. (2011) The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8(+) T Cell Responses of Low Antigen Affinity to Protect against Viral Variants. Immunity 35(1):97-108 |
| abstractText | CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infection to study in vivo consequences, we found that CD27-driven costimulation promoted a CD8(+) T cell response of overall low affinity. These qualitative effects of CD27 on T cell responses were maintained into the memory phase. On a clonal level, CD27-driven costimulation established a higher degree of variety in memory CD8(+) T cells. The benefit became apparent when mice were reinfected, given that CD27 improved CD8(+) T cell responses against reinfection with viral variants, but not with identical virus. We propose that CD27-driven costimulation is a strategy to generate memory clones that have potential reactivity to a wide array of mutable pathogens. |
