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Allele : Tg(HCRT-MJD)1Stak transgene insertion 1, Takeshi Sakurai
Primary Identifier  MGI:2387763 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(HCRT-MJD)1Stak
Strain of Origin  (C57BL/6 x DBA/1)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The transgenic construct contained a carboxy terminal MJD cDNA fragment derived from a patient with Machado-Joseph disease adjoined to a human HCRT promoter. The promoter region consisted of 3.2 kb of 5' upstream region in addition to the the noncoding exon 1. Expression was directed specifically in hypocretin neurons. The MJD fragment contained 77 polyglutamine repeats and was tagged with a Myc epitope tag for histological examination. Expression of the MJD fragment resulted in the ablation of hypocretin containing neurons
  • mutations:
  • Insertion
  • synonyms:
  • orexin/ataxin-3,
  • orexin/ataxin-3,
  • ORX/ATX-Tg,
  • ORX/ATX-Tg
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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2 Carried By

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0 Driven By

38 Publication categories

Trail: Allele




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