| First Author | Moore FL | Year | 2004 |
| Journal | Genomics | Volume | 83 |
| Issue | 5 | Pages | 834-43 |
| PubMed ID | 15081113 | Mgi Jnum | J:265619 |
| Mgi Id | MGI:6201901 | Doi | 10.1016/j.ygeno.2003.11.005 |
| Citation | Moore FL, et al. (2004) Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. Genomics 83(5):834-43 |
| abstractText | Evidence from diverse organisms, including humans, suggests that the DAZ (Deleted in Azoospermia) gene and a closely related homolog, DAZL (DAZ-like), are required early in germ cell development to maintain initial germ cell populations. Here we report the identification and characterization of the DZIP (DAZ-Interacting Protein) gene, which encodes at least three different protein isoforms that contain a C2H2 zinc-finger domain. The DZIP gene is expressed predominantly in human embryonic stem cells and fetal and adult germ cells; moreover, two DZIP protein isoforms colocalize with DAZ and/or DAZL proteins in these tissues. Finally, we provide evidence indicating that DZIP may associate with DAZ and its other cofactors in an RNA-binding protein complex that functions in both ES cells and germ cells. |
