Primary Identifier | MGI:3722177 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Trp53 |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An arginine to histidine substitution was generated at codon 172 (p.R172H, equivalent to p.R175H in humans) by insertion of a targeting construct containing a loxP site flanked neomycin resistance gene cassette and an G-to-A mutation at coding nucleotide 515. Retention of the floxed selection cassette results in inactivation. |