| First Author | Burns ME | Year | 2002 |
| Journal | Neuron | Volume | 36 |
| Issue | 1 | Pages | 81-91 |
| PubMed ID | 12367508 | Mgi Jnum | J:107708 |
| Mgi Id | MGI:3621695 | Doi | 10.1016/s0896-6273(02)00911-x |
| Citation | Burns ME, et al. (2002) Dynamics of cyclic GMP synthesis in retinal rods. Neuron 36(1):81-91 |
| abstractText | In retinal rods, Ca(2+) exerts negative feedback control on cGMP synthesis by guanylate cyclase (GC). This feedback loop was disrupted in mouse rods lacking guanylate cyclase activating proteins GCAP1 and GCAP2 (GCAPs(-/-)). Comparison of the behavior of wild-type and GCAPs(-/-) rods allowed us to investigate the role of the feedback loop in normal rod function. We have found that regulation of GC is apparently the only Ca(2+) feedback loop operating during the single photon response. Analysis of the rods' light responses and cellular dark noise suggests that GC normally responds to light-driven changes in [Ca(2+)] rapidly and highly cooperatively. Rapid feedback to GC speeds the rod's temporal responsiveness and improves its signal-to-noise ratio by minimizing fluctuations in cGMP. |
