| First Author | Hofbauer R | Year | 1987 |
| Journal | Nucleic Acids Res | Volume | 15 |
| Issue | 2 | Pages | 741-52 |
| PubMed ID | 3822814 | Mgi Jnum | J:8613 |
| Mgi Id | MGI:57078 | Doi | 10.1093/nar/15.2.741 |
| Citation | Hofbauer R, et al. (1987) Cell cycle regulated synthesis of stable mouse thymidine kinase mRNA is mediated by a sequence within the cDNA. Nucleic Acids Res 15(2):741-52 |
| abstractText | The cDNA for mouse thymidine kinase (TK) was isolated from a cDNA library in lambda-gt11 and sequenced. It was used as a probe to follow the time course of TK mRNA expression in growth stimulated mouse fibroblasts. Linked to the HSV-TK promoter the cDNA was able to transform LTK-cells to the TK+ phenotype. The transformed cells expressed the TK mRNA and enzyme activity in a growth dependent fashion suggesting that the regulatory element is localized on the cDNA. |
