| First Author | Kim BS | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 1 | Pages | 195-207 |
| PubMed ID | 28978473 | Mgi Jnum | J:254230 |
| Mgi Id | MGI:6104222 | Doi | 10.1016/j.celrep.2017.09.021 |
| Citation | Kim BS, et al. (2017) Generation of RORgammat(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity. Cell Rep 21(1):195-207 |
| abstractText | Th17 cells are potent mediators in autoimmune diseases, and RORgammat is required for their development. Recent studies have shown that RORgammat(+) Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORgammat(+) Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal RORgammat(+) Treg cells in their transcriptomes, peripheral RORgammat(+) Treg cells were derived from Foxp3(+) thymic Treg cells in an antigen-specific manner. Development of these RORgammat(+) Treg cells, coined T regulatory 17 (Tr17) cells, depended on IL-6/Stat3 signaling. Tr17 cells showed suppressive activity against antigen-specific effector T cells in vitro. In addition, Tr17 cells efficiently inhibited myelin-specific Th17-cell-mediated CNS auto-inflammation in a passive EAE model. Collectively, our study demonstrates that Tr17 cells are effector Treg cells that potentially restrict autoimmunity. |
