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Protein Coding Gene : Sftpa1 surfactant associated protein A1
Primary Identifier  MGI:109518 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  20387
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to be involved in positive regulation of phagocytosis. Located in collagen-containing extracellular matrix. Is expressed in extraembryonic component; lung; lung surfactant; and placenta. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to human SFTPA1 (surfactant protein A1) and SFTPA2 (surfactant protein A2).
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired lung response to hyperventilation, reduced resistance to pulmonary infections, and enhanced pulmonary inflammatory response to lipopolysaccharide. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-14380,
  • SP-A,
  • Sftp-1,
  • surfactant-associated protein 1,
  • surfactant associated protein A1,
  • Sftp1,
  • surfactant pulmonary associated protein A1,
  • Sftpa1,
  • SFTPA1,
  • MGD-MRK-14377,
  • MGD-MRK-39517
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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Trail: ProteinCodingGene

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Trail: ProteinCodingGene




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