| First Author | Bishop KD | Year | 2009 |
| Journal | Cell Immunol | Volume | 256 |
| Issue | 1-2 | Pages | 86-91 |
| PubMed ID | 19230866 | Mgi Jnum | J:148554 |
| Mgi Id | MGI:3845702 | Doi | 10.1016/j.cellimm.2009.01.008 |
| Citation | Bishop KD, et al. (2009) Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism. Cell Immunol 256(1-2):86-91 |
| abstractText | Recent studies have implicated the cell surface receptor Programmed Death-1 (PD-1) in numerous models of T cell anergy, though the specific mechanisms by which the PD-1 signal maintains tolerance is not clear. We demonstrate that the depletion of PD-1 with siRNA results in a complete reversal of clonal anergy in the A.E7 T cell model, suggesting that the mechanism by which PD-1 maintains the anergic phenotype is a T-cell-intrinsic phenomenon, and not one dependent on other cell populations in vivo. We have also shown that the neutralization of IL-2 during restimulation abrogates the effect of PD-1 depletion, suggesting that tolerance mediated by PD-1 is wholly IL-2 dependent, and likewise intrinsic to the tolerized cells. |
