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Protein Coding Gene : Wdr45b WD repeat domain 45B
Primary Identifier  MGI:1914090 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  66840
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable TSC1-TSC2 complex binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in cellular response to starvation and macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Orthologous to human WDR45B (WD repeat domain 45B).
PHENOTYPE: Conditional homozygous knockout in neurons affects the Golgi apparatus and mitochondria, which impairs alternative autophagy and leads to neuronal degeneration in the brain and motor deficits. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-33993,
  • AA408735,
  • DNA segment, Chr 16, Brigham & Women's Genetics 0193 expressed,
  • expressed sequence AA408735,
  • MGI:106301,
  • MGI:2143985,
  • Wdr45b,
  • WD repeat domain 45B,
  • 0610008N23Rik,
  • RIKEN cDNA 0610008N23 gene,
  • Wdr45 like,
  • Wdr45l,
  • D16Bwg0193e
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