| Primary Identifier | MGI:1196256 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 99982 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including DNA-binding transcription factor binding activity; histone H3 demethylase activity; and transcription coregulator activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of myeloid cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within DNA repair-dependent chromatin remodeling; negative regulation of neurogenesis; and nervous system development. Located in nucleus. Part of chromatin. Is expressed in several structures, including articular cartilage; brain; reproductive system; retina; and urinary system. Orthologous to human KDM1A (lysine demethylase 1A). PHENOTYPE: Homozygous disruption of this gene results in abnormal gastrulation and early embryonic lethality. Homozygotes lacking the neurospecific isoform are hypoexcitable and display decreased susceptibility to pharmacologically induced seizures. Homozygotes for a hypomorphic allele die perinatally exhibiting heart defects, including ventricular septal defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
