| First Author | Yadav N | Year | 2008 |
| Journal | EMBO Rep | Volume | 9 |
| Issue | 2 | Pages | 193-8 |
| PubMed ID | 18188184 | Mgi Jnum | J:168191 |
| Mgi Id | MGI:4887324 | Doi | 10.1038/sj.embor.7401151 |
| Citation | Yadav N, et al. (2008) CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep 9(2):193-8 |
| abstractText | The coactivator-associated arginine methyltransferase 1 (CARM1) is recruited to gene promoters by many transcription factors. To identify new pathways that use CARM1, we carried out a comprehensive transcriptome analysis of CARM1-knockout embryos. By using complementary DNA microarrays and serial analysis of gene expression, we identified various genes involved in lipid metabolism that were underrepresented in CARM1-knockout embryos, indicating an important role for this coactivator in adipose tissue biology. We also observed that the amount of brown fat in CARM1-knockout embryos is reduced. Furthermore, cells lacking CARM1 have a severely curtailed potential to differentiate into mature adipocytes. Reporter experiments and chromatin immunoprecipitation analysis show that CARM1 regulates these processes by acting as a coactivator for peroxisome proliferator-activated receptor gamma (PPARgamma). Together, these results show that CARM1 promotes adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance. |
