| First Author | He L | Year | 2007 |
| Journal | Nat Rev Cancer | Volume | 7 |
| Issue | 11 | Pages | 819-22 |
| PubMed ID | 17914404 | Mgi Jnum | J:130111 |
| Mgi Id | MGI:3770748 | Doi | 10.1038/nrc2232 |
| Citation | He L, et al. (2007) microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer 7(11):819-22 |
| abstractText | Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network. |
