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Protein Coding Gene : Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase

Primary Identifier  MGI:87860 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  11352
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of establishment of T cell polarity; and synapse maturation. Acts upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; diaphragm; hemolymphoid system gland; hindlimb long bone; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase).
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene display multiple behavioral abnormalities indicating neuronal defects. [provided by MGI curators]
  • synonyms:
  • Abelson related gene,
  • MGD-MRK-1016,
  • MGD-MRK-1391,
  • Abll,
  • Abl2,
  • MGI:2138109,
  • AA536808,
  • Arg,
  • ABL proto-oncogene 2, non-receptor tyrosine kinase,
  • expressed sequence AA536808

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

15 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For