| First Author | Haub O | Year | 1990 |
| Journal | Proc Natl Acad Sci U S A | Volume | 87 |
| Issue | 20 | Pages | 8022-6 |
| PubMed ID | 1700424 | Mgi Jnum | J:10816 |
| Mgi Id | MGI:59261 | Doi | 10.1073/pnas.87.20.8022 |
| Citation | Haub O, et al. (1990) Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. Proc Natl Acad Sci U S A 87(20):8022-6 |
| abstractText | The murine homolog of the fibroblast growth factor-5 (FGF-5) gene has been cloned, and the sequence of the gene's three exons has been determined. The murine gene and the previously isolated human FGF-5 gene are substantially homologous within the coding sequences and in upstream sequences, which contain an additional open reading frame. We have used a portion of the murine gene as probe to detect FGF-5 RNA in adult mouse tissues by both Northern blot and in situ hybridization methods. FGF-5 RNA is present at low levels in widely distributed areas of the central nervous system. Several loci of FGF-5 expression could be localized by in situ hybridization and include portions of the cerebral cortex, hippocampus, and thalamus. Neuronal expression accounts for at least some of the FGF-5 RNA synthesized in the central nervous system. |
