| First Author | Kim HJ | Year | 1992 |
| Journal | J Invest Dermatol | Volume | 98 |
| Issue | 3 | Pages | 359-63 |
| PubMed ID | 1545145 | Mgi Jnum | J:323 |
| Mgi Id | MGI:48861 | Doi | 10.1111/1523-1747.ep12499805 |
| Citation | Kim HJ, et al. (1992) Effect of topical retinoic acids on the levels of collagen mRNA during the repair of UVB-induced dermal damage in the hairless mouse and the possible role of TGF-beta as a mediator. J Invest Dermatol 98(3):359-63 |
| abstractText | Topically applied retinoic acids have been found to enhance the gene expression for collagen types I and III in the skin of UVB-irradiated hairless mice. Prior damage is required because the effect is not observed in the skin of age-matched, non-irradiated control animals. Immunochemical methods have shown an increase in TGF-beta 1 and, to a lesser extent, of TGF-beta 2 in the epidermis following retinoic acid treatment. There were no changes in mRNA levels for any of the isotypes of TGF-beta induced by retinoic acid treatment. This study suggests that TGF-beta may mediate the effect of retinoic acids on dermal repair through the stimulation of collagen gene expression. |
