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Allele : **Tg(HLA-DQA10301,HLA-DQB10302)#Dma** transgene insertion, Daniel M Altmann

Primary Identifier	MGI:6192038	Allele Type	Transgenic
Attribute String	Humanized sequence, Inserted expressed sequence	Gene	*Tg(HLA-DQA10301,HLA-DQB10302)#Dma*
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

Genomic constructs for human MHC gene alleles HLA-DQA1*0301 and HLA-DQB1*0302 were microinjected into fertilized eggs. The resulting transgenic mice express human HLA-DQ8 serotype.

mutations:
Insertion

synonyms:
HLA-DQ8,
HLA-DQ8

earliestPublication:
Boyton RJ, et al. (1998) Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. Int Immunol 10(12):1765-76

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele

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Allele : Tg(HLA-DQA1*0301,HLA-DQB1*0302)#Dma transgene insertion, Daniel M Altmann

External Links

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

Allele : **Tg(HLA-DQA10301,HLA-DQB10302)#Dma** transgene insertion, Daniel M Altmann