| First Author | Vanhalst K | Year | 2001 |
| Journal | FEBS Lett | Volume | 495 |
| Issue | 1-2 | Pages | 120-5 |
| PubMed ID | 11322959 | Mgi Jnum | J:69184 |
| Mgi Id | MGI:1934245 | Doi | 10.1016/s0014-5793(01)02372-9 |
| Citation | Vanhalst K, et al. (2001) The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett 495(1-2):120-5 |
| abstractText | Extensive cDNA analysis demonstrated that all human and mouse protocadherin-beta genes are one-exon genes. The protein sequences of these genes are highly conserved, especially the three most membrane-proximal extracellular domains. Phylogenetic analysis suggested that this unique gene family evolved by duplication of one single protocadherin-beta gene to 15 copies. The final difference in the number of protocadherin-beta genes in man (#19) and mouse (#22) is probably caused by duplications later in evolution. The complex relationship between human and mouse genes and the lack of pseudogenes in the mouse protocadherin-beta gene cluster suggest a species-specific evolutionary pressure for maintenance of numerous protocadherin-beta genes. |
