| First Author | Qi L | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 16 | Pages | 2155-62 |
| PubMed ID | 26143257 | Mgi Jnum | J:225998 |
| Mgi Id | MGI:5695428 | Doi | 10.1016/j.febslet.2015.06.022 |
| Citation | Qi L, et al. (2015) Kindlin-2 interacts with alpha-actinin-2 and beta1 integrin to maintain the integrity of the Z-disc in cardiac muscles. FEBS Lett 589(16):2155-62 |
| abstractText | Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with alpha-actinin-2 at the Z-disc of mouse cardiac muscles and there Kindlin-2 also interacts with beta1 integrin. Knockdown of Kindlin-2 influences the association of beta1 integrin with alpha-actinin-2 and disrupts the structure of the Z-disc and leads to cardiac dysfunction. Our data indicated that Kindlin-2 is a novel alpha-actinin-2-interacting protein and plays an important role in the regulation of cardiac structure and function. |
