| Primary Identifier | MGI:107673 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14187 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including NADP binding activity; geranylgeranyl reductase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in extracellular region and lysosome. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and respiratory system. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). PHENOTYPE: Mice with a knock-out allele exhibit shorter colon crypts, reduced proliferation and maturation of crypt cells, elevated levels of cytokines in the colon mucosa and increased susceptibility to induced colitis and colitis-associated tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
