| First Author | Simonet WS | Year | 1997 |
| Journal | Cell | Volume | 89 |
| Issue | 2 | Pages | 309-19 |
| PubMed ID | 9108485 | Mgi Jnum | J:39641 |
| Mgi Id | MGI:86995 | Doi | 10.1016/s0092-8674(00)80209-3 |
| Citation | Simonet WS, et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89(2):309-19 |
| abstractText | A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These same effects are observed upon administration of recombinant OPG into normal mice. In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG. Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity. |
