| Primary Identifier | MGI:1096342 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 11848 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables GTPase activity. Involved in several processes, including alpha-beta T cell differentiation; negative regulation of oxidative phosphorylation; and regulation of cytoskeleton organization. Acts upstream of or within several processes, including nervous system development; positive regulation of organelle organization; and regulation of systemic arterial blood pressure by hormone. Located in several cellular components, including cytosol; lamellipodium; and ruffle membrane. Is expressed in several structures, including brain; exocrine system; genitourinary system; heart; and pericardial component. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). PHENOTYPE: Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
