| First Author | Smith-Garvin JE | Year | 2010 |
| Journal | Blood | Volume | 116 |
| Issue | 25 | Pages | 5548-59 |
| PubMed ID | 20847203 | Mgi Jnum | J:167402 |
| Mgi Id | MGI:4868172 | Doi | 10.1182/blood-2010-06-292748 |
| Citation | Smith-Garvin JE, et al. (2010) T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool. Blood 116(25):5548-59 |
| abstractText | SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) nucleates a signaling complex critical for T-cell receptor (TCR) signal propagation. Mutations in the tyrosines of SLP-76 result in graded defects in TCR-induced signals depending on the tyrosine(s) affected. Here we use 2 strains of genomic knock-in mice expressing tyrosine to phenylalanine mutations to examine the role of TCR signals in the differentiation of effector and memory CD8(+) T cells in response to infection in vivo. Our data support a model in which altered TCR signals can determine the rate of memory versus effector cell differentiation independent of initial T-cell expansion. Furthermore, we show that TCR signals sufficient to promote CD8(+) T-cell differentiation are different from those required to elicit inflammatory cytokine production. |
