Primary Identifier | MGI:97550 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 18645 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ATP hydrolysis activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Acts upstream of or within positive regulation of actin filament polymerization and regulation of synaptic vesicle exocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). PHENOTYPE: Mice homozygous for a knock-out allele display increased synaptic excitability of neocortical glutamatergic neurons due to higher vesicle exocytosis, hyperactivation of the striatum, hyperactivity, and increased novelty-seeking behavior. [provided by MGI curators] |