| Primary Identifier | MGI:1347244 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 26362 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including negative regulation of cytokine production; nervous system development; and neutrophil clearance. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and extracellular space. Predicted to be part of receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Used to study autoimmune disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). PHENOTYPE: Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
